2. Academic Validation
  3. Recent synthetic and medicinal perspectives of tryptanthrin

Recent synthetic and medicinal perspectives of tryptanthrin

  • Bioorg Med Chem. 2017 Sep 1;25(17):4533-4552. doi: 10.1016/j.bmc.2017.07.003.
Ramandeep Kaur 1,  Sundeep Kaur Manjal 1,  Ravindra K Rawal 1,  Kapil Kumar 2
Affiliations

Affiliations

  • 1 Department of Pharmaceutical Chemistry, Indo-Soviet Friendship College of Pharmacy (ISFCP), Moga, Punjab 142001, India.
  • 2 Department of Pharmaceutical Chemistry, Indo-Soviet Friendship College of Pharmacy (ISFCP), Moga, Punjab 142001, India; School of Pharmaceutical Sciences, Apeejay Stya University, Sohna-Palwal Road, Sohna, Gurgaon, Haryana 122103, India. Electronic address: kapil.py@gmail.com.
PMID: 28720329 DOI: 10.1016/j.bmc.2017.07.003
Abstract

Tryptanthrin is a natural alkaloidal compound having basic indoloquinazoline moiety. It is obtained from various natural plant sources as well as different cell cultures including yeast etc. Trptanthrin is considered as biogenetic precursor for phaitanthrin A-C, pyrroloindoloquinazoline, (±)-cruciferane. Different synthetic approaches for the synthesis of tryptanthrin have been very well reported. It has broad spectrum of biological activities including Anticancer activity, anti-inflammatory, antiprotozoal, antiallergic, antioxidant, and antimicrobial. In this review, our focus will be, on the various approaches for the synthesis of tryptanthrins and its derivatives along with the biological activities.

Keywords

Anticancer; Indoloquinazoline; Phaitanthrin A–C; Pyrroloindoloquinazoline; Tryptanthrin.

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