1. Academic Validation
  2. Antifungal and Cytotoxic β-Resorcylic Acid Lactones from a Paecilomyces Species

Antifungal and Cytotoxic β-Resorcylic Acid Lactones from a Paecilomyces Species

  • J Nat Prod. 2017 Aug 25;80(8):2215-2223. doi: 10.1021/acs.jnatprod.7b00066.
Liangxiong Xu 1 Ping Wu 1 Jinghua Xue 1 Istvan Molnar 2 Xiaoyi Wei 1
Affiliations

Affiliations

  • 1 Key Laboratory of Plant Resources Conservation and Sustainable Utilization/Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences , Guangzhou 510650, People's Republic of China.
  • 2 Natural Products Center, School of Natural Resources and the Environment, University of Arizona , Tucson, Arizona 85706, United States.
Abstract

Eight new β-resorcylic acid lactones (RALs), including the hypothemycin-type compounds paecilomycins N-P (1-3) and the radicicol-type metabolites dechloropochonin I (4), monocillins VI (5) and VII (6), 4'-hydroxymonocillin IV (7), and 4'-methoxymonocillin IV (8), along with nine known RALs (9-17), were isolated from the cultures of Paecilomyces sp. SC0924. Compounds 1 and 2 feature a novel 6/11/5 ring system, and 3 is the first 5'-keto RAL. The structures of 1-8 were elucidated on the basis of extensive spectroscopic analysis, X-ray diffraction analysis, and theoretical calculations of ECD spectra. Compounds 3, 5, and 6 exhibit cytotoxicity against MCF-7, A549, and HeLa cells, and compounds 5 and 7 display Antifungal activity against Peronophythora litchii.

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