2. Academic Validation
  3. Syntheses of cytotoxic novel arctigenin derivatives bearing halogen and alkyl groups on aromatic rings

Syntheses of cytotoxic novel arctigenin derivatives bearing halogen and alkyl groups on aromatic rings

  • Bioorg Med Chem Lett. 2017 Sep 1;27(17):4199-4203. doi: 10.1016/j.bmcl.2017.06.070.
Satoshi Yamauchi 1,  Tuti Wukirsari 2,  Yoshiaki Ochi 2,  Hisashi Nishiwaki 2,  Kosuke Nishi 2,  Takuya Sugahara 3,  Koichi Akiyama 4,  Taro Kishida 3
Affiliations

Affiliations

  • 1 Graduate School of Agriculture, Ehime University, 3-5-7 Tarumi, Matsuyama, Ehime 790-8566, Japan; South Ehime Fisheries Research Center, 1289-1 Funakoshi, Ainan, Ehime 798-4292, Japan. Electronic address: syamauch@agr.ehime-u.ac.jp.
  • 2 Graduate School of Agriculture, Ehime University, 3-5-7 Tarumi, Matsuyama, Ehime 790-8566, Japan.
  • 3 Graduate School of Agriculture, Ehime University, 3-5-7 Tarumi, Matsuyama, Ehime 790-8566, Japan; South Ehime Fisheries Research Center, 1289-1 Funakoshi, Ainan, Ehime 798-4292, Japan.
  • 4 Advanced Research Support Center (ADRES), Ehime University, 3-5-7 Tarumi, Matsuyama, Ehime 790-8566, Japan.
PMID: 28754364 DOI: 10.1016/j.bmcl.2017.06.070
Abstract

The new lignano-9,9'-lactones (α,β-dibenzyl-γ-butyrolactone Lignans), which showed the higher cytotoxicity than arctigenin, were synthesized. The well-known cytotoxic arctigenin showed activity against HL-60 cells (EC50=12μM), however, it was inactive against HeLa cells (EC50>100μM). The synthesized (3,4-dichloro, 2'-butoxy)-derivative 55 and (3,4-dichloro, 4'-butyl)-derivative 66 bearing the lignano-9,9'-lactone structures showed the EC50 values of 10μM and 9.4μM against HL-60 cells, respectively. Against HeLa cells, the EC50 value of the derivative 66 was 27μM. By comparing the activities with the corresponding 9,9'-epoxy structure (tetrahydrofuran compounds), the importance of the lactone structure of 55 and 66 for the higher activities was shown. The substituents on the aromatic ring of the lignano-9,9'-lactones affected the cytotoxicity level, observing more than 10-fold difference.

Keywords

Arctigenin; Lignan; Lignano-9,9′-lactone; Matairesinol; α,β-Dibenzyl-γ-butyrolactone; γ-Butyrolactone.

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