2. Academic Validation
  3. Cytotoxic Prenylated Stilbenes Isolated from Macaranga tanarius

Cytotoxic Prenylated Stilbenes Isolated from Macaranga tanarius

  • J Nat Prod. 2017 Oct 27;80(10):2684-2691. doi: 10.1021/acs.jnatprod.7b00409.
Tiphaine Péresse 1,  Gwenaëlle Jézéquel 1,  Pierre-Marie Allard 2,  Van-Cuong Pham 3,  Doan T M Huong 3,  Florent Blanchard 1,  Jérôme Bignon 1,  Hélène Lévaique 1,  Jean-Luc Wolfender 2,  Marc Litaudon 1,  Fanny Roussi 1
Affiliations

Affiliations

  • 1 Institut de Chimie des Substances Naturelles, CNRS, ICSN UPR2301, University of Paris-Saclay , 91198, Gif-sur-Yvette, France.
  • 2 School of Pharmaceutical Sciences, University of Geneva, University of Lausanne , CMU-Rue Michel Servet 1, 1211 Geneva 11, Switzerland.
  • 3 Advanced Center for Bioorganic Chemistry of the Institute of Marine Biochemistry, Vietnam Academy of Science and Technology , 18 Hoang Quoc Viet, 8404, Caugiay, Hanoi, Vietnam.
PMID: 28972755 DOI: 10.1021/acs.jnatprod.7b00409
Abstract

With the aim of discovering new cytotoxic prenylated Stilbenes of the schweinfurthin series, Macaranga tanarius was selected for detailed phytochemical investigation among 21 Macaranga species examined by using a molecular networking approach. From an ethanol extract of the fruits, seven new prenylated Stilbenes, schweinfurthins K-Q (7-13), were isolated, along with vedelianin (1), schwenfurthins E-G (2-4), mappain (5), and methyl-mappain (6). The structures of the new compounds were established by spectroscopic data analysis. The relative configurations of compounds 8, 12, and 13 were determined based on ROESY NMR spectroscopic analysis. The cytotoxic activities of compounds 1-13 were evaluated against the human glioblastoma (U87) and lung (A549) Cancer cell lines.

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