2. Academic Validation
  3. A human lymphoid-specific transcription factor that activates immunoglobulin genes is a homoeobox protein

A human lymphoid-specific transcription factor that activates immunoglobulin genes is a homoeobox protein

  • Nature. 1988 Dec 8;336(6199):551-7. doi: 10.1038/336551a0.
C Scheidereit 1,  J A Cromlish,  T Gerster,  K Kawakami,  C G Balmaceda,  R A Currie,  R G Roeder
Affiliations

Affiliation

  • 1 Laboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, New York 10021.
PMID: 2904654 DOI: 10.1038/336551a0
Abstract

The human lymphoid-specific transcription factor OTF-2 contains a homoeodomain that is required for DNA binding and binds specifically to DNA elements that are recognized by Drosophila homoeodomain proteins, suggesting coevolutionary relationships between mammalian and invertebrate homoeodomain proteins and their DNA recognition elements.

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