2. Academic Validation
  3. Potential anti-proliferative agents from 1,4-benzoxazinone-quinazolin-4(3H)-one templates

Potential anti-proliferative agents from 1,4-benzoxazinone-quinazolin-4(3H)-one templates

  • Bioorg Med Chem Lett. 2017 Dec 15;27(24):5481-5484. doi: 10.1016/j.bmcl.2017.10.044.
Rajitha Bollu 1,  Saleha Banu 1,  Suresh Kasaboina 1,  Rajashaker Bantu 1,  Lingaiah Nagarapu 2,  Sowjanya Polepalli 3,  Nishant Jain 3
Affiliations

Affiliations

  • 1 Organic Chemistry Division-II (CPC), CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India.
  • 2 Organic Chemistry Division-II (CPC), CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India. Electronic address: nagarapu@iict.res.in.
  • 3 Centre for Chemical Biology, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India.
PMID: 29089233 DOI: 10.1016/j.bmcl.2017.10.044
Abstract

A novel synthetic protocol has been developed for the synthesis of 1,4-benzoxazinone-acetylphenylallyl quinazolin-4(3H)-one hybrids 7a-n by employing Pd-catalyzed CH arylation in presence of 5-10% phosphine ligand in good to excellent yields and evaluated for their anti-proliferative activity against three Cancer cell lines such as A549 (lung), HeLa (cervical), MDA-MB-231 (breast). Compounds 7d, 7f, 7l and 7n exhibited promising anti-proliferative activity with GI50 values ranging from 0.37 to 2.73 µM respectively against A549, HeLa, and MDA-MB-231, while compound 7f showed significant activity against MDA-MB-231 with GI50 value 0.58 µM, 7j showed significant activity against A549 with GI50 value 0.32 µM and 7l showed significant activity against HeLa with GI50 value 0.37 µM. This is the first report on the synthesis and in vitro anti-proliferative evaluation of 1,4-benzoxazinone-acetylphenylallyl quinazolin-4(3H)-one hybrids.

Keywords

1,4-Benzoxazinone; Apoptosis; CC Coupling; Cell lines; Quinazolinone anti-proliferative.

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