2. Academic Validation
  3. Borrelidins F-I, cytotoxic and cell migration inhibiting agents from mangrove-derived Streptomyces rochei SCSIO ZJ89

Borrelidins F-I, cytotoxic and cell migration inhibiting agents from mangrove-derived Streptomyces rochei SCSIO ZJ89

  • Bioorg Med Chem. 2018 May 1;26(8):1488-1494. doi: 10.1016/j.bmc.2018.01.010.
Jianbin Sun 1,  Junli Shao 2,  Changli Sun 3,  Yongxiang Song 3,  Qinglian Li 3,  Laichun Lu 4,  Yunfeng Hu 3,  Chun Gui 5,  Hua Zhang 6,  Jianhua Ju 7
Affiliations

Affiliations

  • 1 CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China; College of Bioengineering, Chongqing UniversIty, Chongqing 400044, China.
  • 2 Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Institute of Laboratory Medicine, Dongguan Key Laboratory of Environmental Medicine, Guangdong Medical University, No. 1 Xincheng Road, Dongguan 523808, China.
  • 3 CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China.
  • 4 College of Bioengineering, Chongqing UniversIty, Chongqing 400044, China.
  • 5 CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China; University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 110039, China.
  • 6 Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Institute of Laboratory Medicine, Dongguan Key Laboratory of Environmental Medicine, Guangdong Medical University, No. 1 Xincheng Road, Dongguan 523808, China. Electronic address: huazhang@gdmu.edu.cn.
  • 7 CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China; University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 110039, China. Electronic address: jju@scsio.ac.cn.
PMID: 29452840 DOI: 10.1016/j.bmc.2018.01.010
Abstract

Borrelidin A (1) is produced by several species of Streptomyces and within its bioactive scaffold, the vinylic nitrile moiety is essential for activity. We report herein newly discovered members of the borrelidin family, borrelidin F (2), borrelidin G (3), borrelidin H (4) and borrelidin I (5); all were isolated from Streptomyces rochei SCSIO ZJ89 originating from a mangrove-derived sediment sample. These structurally diverse metabolites enabled a number of new structure-activity relationships (SARs) to be identified, especially with respect to the different configurations at the C11-OH and C12-C15 double bonds for which the absolute configurations were determined using spectroscopic methods. Importantly, borrelidin H (4) was found to have a therapeutic window superior to that of borrelidin A (1) in vitro and could inhibit migration of Cancer cells.

Keywords

Borrelidin; Cancer; Cytotoxic activity; Migration; Streptomyces.

Figures