2. Academic Validation
  3. Anti-Inflammatory Isoquinoline with Bis- seco-aporphine Skeleton from Dactylicapnos scandens

Anti-Inflammatory Isoquinoline with Bis- seco-aporphine Skeleton from Dactylicapnos scandens

  • Org Lett. 2018 Mar 16;20(6):1647-1650. doi: 10.1021/acs.orglett.8b00400.
Bei Wang 1 2,  Zi-Feng Yang 3,  Yun-Li Zhao 1,  Ya-Ping Liu 1,  Jun Deng 1,  Wan-Yi Huang 3,  Xiao-Nian Li 1,  Xin-Hua Wang 3,  Xiao-Dong Luo 1 3
Affiliations

Affiliations

  • 1 State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , People's Republic of China.
  • 2 University of Chinese Academy of Sciences , Beijing 100049 , People's Republic of China.
  • 3 Guangzhou Medical University , Guangzhou 511436 , People's Republic of China.
PMID: 29508621 DOI: 10.1021/acs.orglett.8b00400
Abstract

Dactyllactone A (1), which was isolated from Dactylicapnos scandens, is an isoquinoline alkaloid with a rearranged and reconstructed D ring, making it the first of a new subtype of aporphines. Compound 1 might be derived from a common aporphine skeleton, which may have undergone biogenetic rearrangement and cleavage of the aromatic ring. Its structure was determined by extensive spectroscopic analysis and single-crystal X-ray diffraction. Compound 1 exhibited anti-inflammatory activity in vitro significantly by inhibiting the expression of IL-1β and PGE2 in a dose-dependent manner.

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