Melanogenesis inhibitory pregnane glycosides from Cynanchum atratum

Bioorg Med Chem Lett. 2018 Apr 15;28(7):1252-1256. doi: 10.1016/j.bmcl.2018.01.004.

Qinghao Jin ¹, Xiang Hua Han ¹, Cheong-Yong Yun ¹, Chul Lee ¹, Jin Woo Lee ¹, Dongho Lee ², Mi Kyeong Lee ¹, Sang-Hun Jung ³, Jin Tae Hong ¹, Youngsoo Kim ¹, Bang Yeon Hwang ⁴

Affiliations

1 College of Pharmacy, Chungbuk National University, Cheongju 28160, Republic of Korea.
2 School of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
3 College of Pharmacy, Chungnam National University, Daejeon 34134, Republic of Korea.
4 College of Pharmacy, Chungbuk National University, Cheongju 28160, Republic of Korea. Electronic address: byhwang@chungbuk.ac.kr.

PMID: 29526485 DOI: 10.1016/j.bmcl.2018.01.004

Abstract

Bioassay-guided fractionation of the methanolic extract from the roots of Cynanchum atratum has resulted in the isolation of three new pregnane glycosides (1-3) along with four known compounds (4-7). Their structures were identified by analysis of the spectroscopic data including extensive 2D NMR. All of the isolates were evaluated for their potential to inhibit the melanin production in α-melanocyte stimulating hormone (α-MSH)-activated B16 melanoma cells. Of these, compounds 4-7 dose-dependently inhibited the melanin production with the IC₅₀ values ranging from 4 μM to 33 μM.

Keywords

Asclepiadaceae; Cynanchum atratum; Melanogenesis inhibitor; Pregnane glycosides; α-MSH.

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