2. Academic Validation
  3. PMN inhibits colorectal cancer cells through inducing mitotic arrest and p53-dependent apoptosis via the inhibition of tubulin polymerization

PMN inhibits colorectal cancer cells through inducing mitotic arrest and p53-dependent apoptosis via the inhibition of tubulin polymerization

  • Biochem Biophys Res Commun. 2018 May 23;499(4):927-933. doi: 10.1016/j.bbrc.2018.04.021.
Xingkang Wu 1,  Yuemao Shen 2
Affiliations

Affiliations

  • 1 Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan, Shandong 250012, PR China.
  • 2 Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan, Shandong 250012, PR China; State Key Laboratory of Microbial Technology, Shandong University, No. 27 South Shanda Road, Jinan, Shandong 250100, PR China. Electronic address: yshen@sdu.edu.cn.
PMID: 29626471 DOI: 10.1016/j.bbrc.2018.04.021
Abstract

Colorectal Cancer (CRC) is the third most prevalent malignancy worldwide. New understandings about this disease are urgently required to guide clinical therapies. In this study, we focused on the effects of the small molecule PMN on CRC cells. PMN dose-dependently inhibited CRC cell proliferation through inducing mitotic arrest and Apoptosis. PMN induced mitotic arrest via the disruption of spindle apparatus by inhibiting microtubule polymerization. PMN-induced mitotic arrest resulted in Apoptosis and p53 upregulation. Furthermore, p53 upregulation sensitized PMN-induced mitotic cells to Apoptosis. This study deepens the understanding of the effects of p53 on the response of CRC cells to PMN, providing the basis for the potential development of PMN as a lead compound of microtubule-destabilizers for p53-positive CRC treatment.

Keywords

Apoptosis; Colorectal cancer; Microtubule; Mitotic arrest; PMN; p53.

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