2. Academic Validation
  3. Chemokine receptor antagonist block inflammation and therapy Japanese encephalitis virus infection in mouse model

Chemokine receptor antagonist block inflammation and therapy Japanese encephalitis virus infection in mouse model

  • Cytokine. 2018 Oct;110:70-77. doi: 10.1016/j.cyto.2018.04.022.
Ke Liu 1,  Changguang Xiao 1,  Feifei Wang 2,  Xiao Xiang 1,  Anni Ou 1,  Jianchao Wei 1,  Beibei Li 1,  Donghua Shao 1,  Denian Miao 3,  Fanfan Zhao 4,  Gang Long 4,  Yafeng Qiu 1,  Huaimin Zhu 5,  Zhiyong Ma 6
Affiliations

Affiliations

  • 1 Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, No. 518, Ziyue Road, Shanghai 200241, PR China.
  • 2 Molecular Virology and Comparative Medicine, Teaching Building Room 420&422, Nanjing Agricultural University, Nanjing, Jiangsu 210095, PR China.
  • 3 Shanghai Academy of Agricultural Sciences, Shanghai 201106, PR China.
  • 4 Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, PR China.
  • 5 Department of Pathogen Biology, Second Military Medical University, Shanghai 200433, PR China.
  • 6 Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, No. 518, Ziyue Road, Shanghai 200241, PR China. Electronic address: ZYMA811@aliyun.com.
PMID: 29704821 DOI: 10.1016/j.cyto.2018.04.022
Abstract

Japanese encephalitis (JE) is a viral encephalitis disease caused by Infection with the Japanese encephalitis virus (JEV). The virus can cross the blood-brain barrier and cause death or long-term sequela in infected humans or Animals. In this study, we first investigated the distribution of JEV Infection in brain and further analyzed the dynamic change in inflammation related genes, chemokines, as well as pathological characteristics. Results demonstrated that CCR2 and CCR5 Antagonist could significantly inhibit the inflammation. The mice treated with CCR2 and CCR5 antagonists had a higher survival rate between 60% and 70%, respectively. In summary, our study thoroughly illustrated the characteristics of the dynamic change in inflammation related genes and chemokines induced by JEV Infection. We further indicated that CCR5 and CCR2 are potential targets for treatment of JE.

Keywords

Chemokines; Inflammation related genes; Japanese encephalitis virus.

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