2. Academic Validation
  3. Four New Lignans from Kadsura Interior and Their Bioactivity

Four New Lignans from Kadsura Interior and Their Bioactivity

  • Molecules. 2018 May 26;23(6):1279. doi: 10.3390/molecules23061279.
Jiu-Shi Liu 1,  Jin Zhang 2 3,  Yao-Dong Qi 4,  Xiao-Guang Jia 5,  Ben-Gang Zhang 6,  Hai-Tao Liu 7
Affiliations

Affiliations

  • 1 Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China. liujiushi90@163.com.
  • 2 Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China. jzhang419@163.com.
  • 3 Institute of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830011, China. jzhang419@163.com.
  • 4 Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China. ydqi@implad.ac.cn.
  • 5 Institute of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830011, China. jxyxj2003@163.com.
  • 6 Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China. bgzhang@implad.ac.cn.
  • 7 Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China. htliu0718@126.com.
PMID: 29861462 DOI: 10.3390/molecules23061279
Abstract

A phytochemical investigation of the stems of Kadsura interior has led to an isolation of four new Lignans, named kadsutherin E⁻H (1⁻4), together with two known Lignans (5⁻6). The structures of the four new compounds were established on the basis of comprehensive spectroscopic analyses. Compounds 1⁻6 exhibited inhibition against adenosine diphosphate (ADP) induced platelet aggregation. Among the isolated compounds, kadsutherin F (2) showed the strongest anti-platelet aggregation activity with an inhibition of 49.47%.

Keywords

Kadsura interior; anti-platelet aggregation; kadsutherin E-H; lignan.

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