2. Academic Validation
  3. Synthesis, antioxidant and antitumoral activities of 5'-arylchalcogeno-3-aminothymidine (ACAT) derivatives

Synthesis, antioxidant and antitumoral activities of 5'-arylchalcogeno-3-aminothymidine (ACAT) derivatives

  • Medchemcomm. 2016 Dec 22;8(2):408-414. doi: 10.1039/c6md00640j.
Raquel Mello da Rosa 1,  Bruna Candia Piccoli 2,  Fernanda D'Avila da Silva 2,  Luciano Dornelles 1,  João B T Rocha 2,  Mariana Souza Sonego 3,  Karine Rech Begnini 3,  Tiago Collares 3,  Fabiana K Seixas 3,  Oscar E D Rodrigues 1
Affiliations

Affiliations

  • 1 LabSelen-NanoBio - Departamento de Química , Universidade Federal de Santa Maria , Santa Maria , Brazil . Email: rodriguesoed@gmail.com.
  • 2 Programa de Pós-graduação em Ciências Biológicas: Bioquímica Toxicológica , Universidade Federal de Santa Maria , Santa Maria , Brazil.
  • 3 Molecular and Cellular Oncology Group , Graduate Program in Biotechnology , Universidade Federal de Pelotas , Pelotas , Brazil.
PMID: 30108758 DOI: 10.1039/c6md00640j
Abstract

This article presents the preparation and in vitro biological activities of new 5'-arylchalcogeno-3-aminothymidine derivatives as Antioxidants (inhibition of lipid peroxidation, scavenging of the free radical 2,2-diphenylpicrylhydrazyl and demonstration of a thiol peroxidase-like activity) as well as antitumoral agents against bladder carcinoma 5637. The chalcogeno-aminothymidines presented prominent activity in the tests for both biological properties, showing a direct relation with the chalcogenium atom.

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