2. Academic Validation
  3. 3,4- seco-Norclerodane Diterpenoids from the Roots of Polyalthia laui

3,4- seco-Norclerodane Diterpenoids from the Roots of Polyalthia laui

  • J Nat Prod. 2019 Jan 25;82(1):27-34. doi: 10.1021/acs.jnatprod.8b00243.
Zhang-Xin Yu 1 2,  Cai-Juan Zheng 1,  Guang-Ying Chen 1,  Rong-Li Huang 1,  Xue-Ming Zhou 1,  Zhi-Gang Niu 1,  Xiao-Bao Li 1,  Chang-Ri Han 1 3,  Xiao-Ping Song 1 3
Affiliations

Affiliations

  • 1 Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education , Hainan Normal University , Haikou 571158 , People's Republic of China.
  • 2 Hainan Branch of the Institute of Medicinal Plant Development , Chinese Academy of Medical Sciences and Peking Union Medical College , Haikou 570311 , People's Republic of China.
  • 3 Key Laboratory of Medicinal and Edible Plant Resources of Hainan Province , Hainan Institute of Science and Technology , Haikou 571126 , People's Republic of China.
PMID: 30596489 DOI: 10.1021/acs.jnatprod.8b00243
Abstract

Ten new clerodane Diterpenoids, polylauioids A-J (1-10), and five known analogues (11-15) were isolated from the roots of Polyalthia laui. Among the new compounds, 3 and 8 are artifacts. The structures were elucidated using spectroscopic methods and by comparison with published NMR spectroscopic data. The absolute configurations of 4, 5, and 7 were defined based on single-crystal X-ray diffraction and electronic circular dichroism data. Compounds 1 and 2 represent the first examples of rearranged 3,4- seco-norclerodane Diterpenoids, and a putative biosynthesis pathway for these compounds is proposed. Compounds 1, 4, 6, 7, 9, and 10 showed anti-HIV activities with EC50 values ranging from 12.2 to 35.2 μM.

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