2. Academic Validation
  3. Screening of the Pathogen Box reveals new starting points for anti-trypanosomal drug discovery

Screening of the Pathogen Box reveals new starting points for anti-trypanosomal drug discovery

  • Medchemcomm. 2018 Oct 26;9(12):2037-2044. doi: 10.1039/c8md00319j.
Clinton G L Veale 1,  Heinrich C Hoppe 2
Affiliations

Affiliations

  • 1 School of Chemistry and Physics , Pietermaritzburg Campus , University of KwaZulu-Natal , Private Bag X01 , Scottsville , 3209 , South Africa . Email: VealeC@ukzn.ac.za ; Tel: +27 33 260 6365.
  • 2 Department of Biochemistry and Microbiology , Rhodes University , Grahamstown , 6140 , South Africa . Email: H.Hoppe@ru.ac.za ; Tel: +27 46 603 8262.
PMID: 30647879 DOI: 10.1039/c8md00319j
Abstract

This study aimed to uncover new starting points for anti-trypansomal drug discovery through the screening of the Pathogen Box against Trypanosoma brucei brucei. Our study identified compounds 35, 39, 46, 53 and 56 whose activity and selectivity highlighted them as promising candidates with potential for further study and optimisation.

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