2. Academic Validation
  3. Another look at phenolic compounds in cancer therapy the effect of polyphenols on ubiquitin-proteasome system

Another look at phenolic compounds in cancer therapy the effect of polyphenols on ubiquitin-proteasome system

  • Eur J Med Chem. 2019 Apr 1:167:291-311. doi: 10.1016/j.ejmech.2019.01.044.
Aleksandra Golonko 1,  Tomasz Pienkowski 2,  Renata Swislocka 2,  Ryszard Lazny 3,  Marek Roszko 1,  Wlodzimierz Lewandowski 4
Affiliations

Affiliations

  • 1 Department of Food Analysis, Institute of Agricultural and Food Biotechnology, Rakowiecka 36, 02-532, Warsaw, Poland.
  • 2 Bialystok University of Technology, Faculty of Civil Engineering and Environmental Engineering, Department of Chemistry, Biology and Biotechnology, Wiejska 45E, 15-351, Bialystok, Poland.
  • 3 Institut of Chemistry, University of Bialystok, Ciolkowskiego 1K, 15-245, Bialystok, Poland.
  • 4 Department of Food Analysis, Institute of Agricultural and Food Biotechnology, Rakowiecka 36, 02-532, Warsaw, Poland. Electronic address: w-lewando@wp.pl.
PMID: 30776692 DOI: 10.1016/j.ejmech.2019.01.044
Abstract

Inhibitors of the ubiquitin-proteasome system (UPS) have been the object of research interests for many years because of their potential as anti-cancer agents. Research in this field is aimed at improving the specificity and safety of known Proteasome inhibitors. Unfortunately, in vitro conditions do not reflect the processes taking place in the human body. Recent reports indicate that the components of human plasma affect the course of many signaling pathways, Proteasome activity and the effectiveness of synthetic cytostatic drugs. Therefore, it is believed that the key issue is to determine the effects of components of the human diet, including effects of chemically active Polyphenols on the ubiquitin-proteasome system activity in both physiological and pathological (cancerous) states. The following article summarizes the current knowledge on the direct and indirect synergistic and antagonistic effects between polyphenolic compounds present in the human diet and the efficiency of protein degradation via the UPS.

Keywords

Cancer treatment; Cellular metabolism; Molecular docking; Polyphenols activity; Proteasome inhibitors.

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