2. Academic Validation
  3. Insights into Triterpene Acids in Fermented Mycelia of Edible Fungus Poria cocos by a Comparative Study

Insights into Triterpene Acids in Fermented Mycelia of Edible Fungus Poria cocos by a Comparative Study

  • Molecules. 2019 Apr 4;24(7):1331. doi: 10.3390/molecules24071331.
Jian Jin 1,  Rongrong Zhou 2 3,  Jing Xie 4,  Huixuan Ye 5,  Xuejuan Liang 6,  Can Zhong 7,  Bingbing Shen 8,  You Qin 9,  Shuihan Zhang 10 11,  Luqi Huang 12 13
Affiliations

Affiliations

  • 1 Institute of Chinese Materia Medica, Hunan Academy of Chinese Medicine, Changsha 410013, China. jinjian2016@163.com.
  • 2 College of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, China. rz172@georgetown.edu.
  • 3 National Resource Center for Chinese Meteria Medica, Chinese Academy of Chinese Medical Sciences, Beijing 100700, China. rz172@georgetown.edu.
  • 4 Institute of Chinese Materia Medica, Hunan Academy of Chinese Medicine, Changsha 410013, China. axxj2057@163.com.
  • 5 Jiuzhitang Co., Ltd, Changsha 410205, China. yehuixuan2019@163.com.
  • 6 Institute of Chinese Materia Medica, Hunan Academy of Chinese Medicine, Changsha 410013, China. guole18888@163.com.
  • 7 Institute of Chinese Materia Medica, Hunan Academy of Chinese Medicine, Changsha 410013, China. canzhong651@163.com.
  • 8 Institute of Chinese Materia Medica, Hunan Academy of Chinese Medicine, Changsha 410013, China. shenbingbing24@126.com.
  • 9 Institute of Chinese Materia Medica, Hunan Academy of Chinese Medicine, Changsha 410013, China. 20162010@stu.hnucm.edu.cn.
  • 10 Institute of Chinese Materia Medica, Hunan Academy of Chinese Medicine, Changsha 410013, China. zhangshuihan0220@126.com.
  • 11 2011 Collaboration and Innovation Center for Digital Chinese Medicine in Hunan, Changsha 410208, China. zhangshuihan0220@126.com.
  • 12 College of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, China. huangluqi01@126.com.
  • 13 National Resource Center for Chinese Meteria Medica, Chinese Academy of Chinese Medical Sciences, Beijing 100700, China. huangluqi01@126.com.
PMID: 30987348 DOI: 10.3390/molecules24071331
Abstract

As an edible sclerotia-forming fungus, Poria cocos is widely used as a food supplement and as a tonic in China. High-performance liquid chromatography-quadrupole/time-of-flight mass spectrometry (HPLC-QTOF-MS/MS) was applied to identify triterpene acids in fermented mycelia of P. cocos, as well as the epidermis and inner part of natural sclerotia. A total of 19 triterpene acids were identified in fermented mycelia, whereas 31 were identified in the epidermis and 24 in the inner part. Nine triterpene acids were quantitatively determined, and the concentrations of two valuable Triterpenes, dehydropachymic acid and pachymic acid, reached 1.07 mg/g and 0.61 mg/g in the fermented mycelia part, respectively, and were both significantly higher than the concentration in the two natural parts. The fermented mycelia could be a good choice for producing some target triterpene compounds and functional foods through fermentation thanks to the high concentration of some triterpene acids.

Keywords

HPLC-QTOF-MS/MS; fungi; mycelium; sclerotium; triterpene.

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