2. Academic Validation
  3. Strepantibins A-C: Hexokinase II Inhibitors from a Mud Dauber Wasp Associated Streptomyces sp

Strepantibins A-C: Hexokinase II Inhibitors from a Mud Dauber Wasp Associated Streptomyces sp

  • J Nat Prod. 2019 May 24;82(5):1114-1119. doi: 10.1021/acs.jnatprod.8b00821.
Ya-Jie Song 1,  Hong-Bo Zheng 2,  Ai-Hong Peng 1,  Jia-Hui Ma 1,  Dan-Dan Lu 1,  Xia Li 1 3,  Hang-Yu Zhang 4,  Wei-Dong Xie 1 3
Affiliations

Affiliations

  • 1 Department of Pharmacy, College of Marine Science , Shandong University at Weihai , Weihai 264209 , People's Republic of China.
  • 2 Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Science , Shandong University , Jinan 250012 , People's Republic of China.
  • 3 Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences , Guiyang 550002 , People's Republic of China.
  • 4 Department of Biomedical Engineering, Faculty of Electronic Information and Electrical Engineering , Dalian University of Technology , Dalian 116024 , People's Republic of China.
PMID: 31013087 DOI: 10.1021/acs.jnatprod.8b00821
Abstract

Two new p-terphenyls, strepantibins A and B (1 and 2), along with the first representative of a naturally occurring bisphenyltropone, strepantibin C (3), were characterized from a Streptomyces sp. associated with the larvae of the mud dauber wasp Sceliphron madraspatanum. Their structures were determined by high-resolution electrospray ionization mass spectrometry, NMR, and X-ray crystallography data interpretation. Strepantibins A-C inhibited Hexokinase II (HK2) activity and displayed antiproliferative activity against hepatoma carcinoma cells HepG-2, SMMC-7721 and plc-prf-5. In SMMC-7721 cells treated with strepantibin A, the morphological characteristics of Apoptosis were observed.

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