2. Academic Validation
  3. Antiviral activity of brequinar against foot-and-mouth disease virus infection in vitro and in vivo

Antiviral activity of brequinar against foot-and-mouth disease virus infection in vitro and in vivo

  • Biomed Pharmacother. 2019 Aug;116:108982. doi: 10.1016/j.biopha.2019.108982.
Shi-Fang Li 1,  Mei-Jiao Gong 1,  Yue-Feng Sun 2,  Jun-Jun Shao 2,  Yong-Guang Zhang 2,  Hui-Yun Chang 3
Affiliations

Affiliations

  • 1 State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, Gansu, China.
  • 2 State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, Gansu, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu 225009, China.
  • 3 State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, Gansu, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu 225009, China. Electronic address: changhuiyun@caas.cn.
PMID: 31146110 DOI: 10.1016/j.biopha.2019.108982
Abstract

Foot-and-mouth disease (FMD) is one of the most highly contagious animal disease that affects cloven-hoofed Animals. However, the FMD vaccine does not provide effective protection until adaptive immune protection elicited by the vaccination occurs. Therefore, an alternative application of Antiviral agents for inhibition of the FMD virus (FMDV) is needed. Here, we demonstrated that brequinar could exhibit Antiviral activity in swine kidney cells (IBRS-2 cells) infected with two different FMDV serotypes. Subsequently, in vivo activity of brequinar was confirmed in a mouse model of Infection. Specifically, brequinar at a concentration of 50 μg, provided 25% protection for 5 days following FMDV challenge. These results suggested that brequinar could be used as effective Antiviral agent against FMD.

Keywords

Antiviral activity; Brequinar; Foot and mouth disease virus; Suckling mouse; in vivo.

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