2. Academic Validation
  3. Absolute Configuration and Biological Activities of Meroterpenoids from an Endophytic Fungus of Lycium barbarum

Absolute Configuration and Biological Activities of Meroterpenoids from an Endophytic Fungus of Lycium barbarum

  • J Nat Prod. 2019 Aug 23;82(8):2229-2237. doi: 10.1021/acs.jnatprod.9b00288.
Yi Long 1,  Ting Tang 1,  Li-Ying Wang 2,  Bin He 2,  Kun Gao 1
Affiliations

Affiliations

  • 1 State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering , Lanzhou University , Lanzhou 730000 , People's Republic of China.
  • 2 Ningxia Senmiao Goji Technology and Development Co., Ltd. , Yinchuan 750000 , People's Republic of China.
PMID: 31397570 DOI: 10.1021/acs.jnatprod.9b00288
Abstract

Eleven new meroterpenoids, bipolahydroquinones A-C (1-3), cochlioquinones I-N (4-8 and 11), and isocochlioquinones F and G (9 and 10), together with six known ones, were obtained from an endophytic fungus Bipolaris sp. L1-2 from Lycium barbarum. Compound 2 is the first example of cochlioquinone derivatives possessing a benzofuran moiety. The structures and absolute configurations of the new compounds were elucidated by spectroscopic data interpretation, single-crystal X-ray diffraction analysis, chemical transformations, and biosynthetic considerations. Compounds 3, 4, and 6-8 showed cytotoxicity against NCI-H226 and/or MDA-MB-231 with IC50 values ranging from 5.5 to 9.5 μM.

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