2. Academic Validation
  3. Anti-Inflammatory and anti-proliferative oleanane-type triterpene glycosides from the vine of Momordica cochinchinensis

Anti-Inflammatory and anti-proliferative oleanane-type triterpene glycosides from the vine of Momordica cochinchinensis

  • Nat Prod Res. 2021 Aug;35(16):2707-2714. doi: 10.1080/14786419.2019.1666383.
Hung-Tse Huang 1 2,  Yu-Chi Lin 1,  Li-Jie Zhang 1,  Chia-Ching Liaw 1 3,  Hsin-Yen Chen 4,  Ming-Tung Hsueh 4,  Yao-Haur Kuo 1 5
Affiliations

Affiliations

  • 1 Division of Chinese Materia Medica Development, National Research Institute of Chinese Medicine, Taipei, Taiwan.
  • 2 Department of Biochemical Science and Technology, National Taiwan University, Taipei, Taiwan.
  • 3 Department of Biochemical Science and Technology, National Chiayi University, Chiayi, Taiwan.
  • 4 Taitung District Agricultural Research and Extension Station, Council of Agriculture, Taitung, Taiwan.
  • 5 Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan.
PMID: 31533481 DOI: 10.1080/14786419.2019.1666383
Abstract

This research isolated two new oleanane-type triterpene glycosides, named mocochinosides A (1) and B (2), together with ten known compounds as chikusetsusaponin IVa ethyl ester (3), momordin Ib (4), momordin IIb (5), momordin II (6), calenduloside G (7), calenduloside H (8), elatoside A (9), elatoside C (10), calendulaglycoside C 6'-O-7-butyl ester (11), and hederagenin 3-O-β-D-glucuronopyranoside (12) and characterized them from the vines of Momordica cochinchinensis. The new structures of both glycosides 1-2 were elucidated by spectroscopic analysis including 2 D NMR and MS, followed by an analysis of their anti-inflammatory and cytotoxic activities. Compounds 1, 4, and 11 showed moderate inhibitions for NO production on RAW264.7 macrophages induced by LPS at IC50 5.41 ∼ 11.28 μM. Compounds 3, 4, and 7 (IC50 8.42 ∼ 19.74 μM) exhibited potential anti-proliferative activities against both of WiDr and MCF-7 human tumor cell lines.

Keywords

Momordica cochinchinensis; anti-inflammatory; anti-proliferation; mocochinoside; oleanane-type triterpene glycoside.

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