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  3. Urinary biomarkers of phthalates exposure and risks of thyroid cancer and benign nodule

Urinary biomarkers of phthalates exposure and risks of thyroid cancer and benign nodule

  • J Hazard Mater. 2020 Feb 5;383:121189. doi: 10.1016/j.jhazmat.2019.121189.
Chong Liu 1,  Yan-Ling Deng 1,  Tong-Zhang Zheng 2,  Pan Yang 1,  Xue-Qing Jiang 3,  Er-Nan Liu 4,  Xiao-Ping Miao 5,  Long-Qiang Wang 6,  Ming Jiang 7,  Qiang Zeng 8
Affiliations

Affiliations

  • 1 Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
  • 2 Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA.
  • 3 Department of Thyroid and Breast Surgery, the Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
  • 4 Wuhan Center for Disease Prevention and Control, Wuhan, Hubei, PR China.
  • 5 Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China; Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
  • 6 Department of Thyroid and Breast Surgery, the Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China. Electronic address: 187155071@qq.com.
  • 7 Department of Thyroid and Breast Surgery, the Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China. Electronic address: jm0911@sina.com.
  • 8 Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China; Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA. Electronic address: zengqiang506@163.com.
PMID: 31541958 DOI: 10.1016/j.jhazmat.2019.121189
Abstract

Phthalates have been reported to affect the function and growth of thyroid. However, there is little data on the effect of phthalates on thyroid oncogenesis. Here we explored the associations between phthalates exposure and the risks of thyroid Cancer and benign nodule. We sex-matched 144 thyroid Cancer, 138 benign nodule patients and 144 healthy adults from Wuhan, China. Eight phthalate metabolites in spot urine samples were quantified using high-performance liquid chromatography and tandem mass spectrometry. The associations of creatinine-corrected urinary phthalate metabolites with the risks of thyroid Cancer and benign nodule were assessed using multivariable logistic regression models. We found that urinary monomethyl phthalate (MMP), mono(2-ethyl-5hydroxyhexyl) phthalate (MEHHP) and mono(2-ethylhexyl) phthalate (MEHP) associated with increased risks of thyroid Cancer and nodule, with adjusted odds ratios (ORs) ranging from 1.74 to 4.78 comparing the extreme tertiles, and urinary monobutyl phthalate (MBP) was associated with decreased risks of thyroid Cancer and benign nodule (all P for trends < 0.05). Male-specific positive associations of urinary monoethyl phthalate (MEP) with thyroid Cancer and nodule as well as urinary mono(2-ethyl-5-oxohexyl) phthalate (MEOHP) with thyroid Cancer were also observed. Our results suggest that exposure to certain phthalates may contribute to increased risks of thyroid Cancer and benign nodule.

Keywords

Case-control study; Exposure; Phthalates; Thyroid benign nodule; Thyroid cancer.

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