2. Academic Validation
  3. Lignans from Saururus chinensis with Inhibitory Effects on Nitric Oxide Production

Lignans from Saururus chinensis with Inhibitory Effects on Nitric Oxide Production

  • J Nat Prod. 2019 Nov 22;82(11):3002-3009. doi: 10.1021/acs.jnatprod.9b00520.
Qinghao Jin 1,  Jin Woo Lee 1,  Jun Gu Kim 1,  Dongho Lee 2,  Jin Tae Hong 1,  Youngsoo Kim 1,  Mi Kyeong Lee 1,  Bang Yeon Hwang 1
Affiliations

Affiliations

  • 1 College of Pharmacy , Chungbuk National University , Cheongju 28160 , South Korea.
  • 2 Department of Biosystems and Biotechnology, College of Life Sciences and Biotechnology , Korea University , Seoul 02841 , South Korea.
PMID: 31642320 DOI: 10.1021/acs.jnatprod.9b00520
Abstract

Three biogenetically related ent-sauchinone-type Lignans (1-3), four 8-O-4'-type neolignans (4-7), a diaryldimethylbutane lignan (8), and a cyclic carbonate (9), along with 12 known compounds, have been isolated from a methanol extract of the aerial parts of Saururus chinensis. The structures of the new compounds (1-9) were determined by analysis of their 1D and 2D NMR spectra, HRESIMS, and ECD data. A putative biosynthetic pathway for the three ent-sauchinone-type Lignans (1-3) was postulated. Compounds 1, 7, and 10 showed inhibitory effects on LPS-induced NO production in RAW 264.7 cells with IC50 values of 5.6, 8.6, and 9.2 μM, respectively.

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