Cytotoxic p-Terphenyls from a Marine-Derived Nocardiopsis Species

J Nat Prod. 2019 Dec 27;82(12):3504-3508. doi: 10.1021/acs.jnatprod.9b00963.

Dongyang Wang ¹, Yi Wang ¹, Yinfeng Ouyang ¹, Peng Fu ¹ ², Weiming Zhu ¹ ²

Affiliations

1 Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy , Ocean University of China , Qingdao 266003 , China.
2 Open Studio for Druggability Research of Marine Natural Products, Laboratory for Marine Drugs and Bioproducts , Pilot National Laboratory for Marine Science and Technology (Qingdao) , Qingdao 266003 , China.

PMID: 31820976 DOI: 10.1021/acs.jnatprod.9b00963

Abstract

Three new p-terphenyl derivatives, nocarterphenyls A-C (1-3), along with three known analogues (4-6) were isolated from the marine-derived actinobacterial strain Nocardiopsis sp. OUCMDZ-4936. Their structures were elucidated on the basis of spectroscopic analysis and a single-crystal X-ray diffraction experiment. Compounds 1 and 2 possess a benzothiazole and benzothiazine moiety, respectively, which are rare in the skeleton of p-terphenyls. Nocarterphenyl A (1) showed potent cytotoxic activity against the HL60 and HCC1954 Cancer cell lines with the IC₅₀ values of 0.38 and 0.10 μM among 26 human Cancer cell lines.

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