2. Academic Validation
  3. Cytotoxic effects of flavonoids from root of Sophora flavescens in cancer cells

Cytotoxic effects of flavonoids from root of Sophora flavescens in cancer cells

  • Nat Prod Res. 2021 Nov;35(22):4317-4322. doi: 10.1080/14786419.2020.1712382.
Xiao-Bin Huang 1,  Luo-Wei Yuan 2,  Jing Shao 1,  Yan Yang 1,  Yi Liu 3,  Jin-Jian Lu 2 4,  Lei Chen 1
Affiliations

Affiliations

  • 1 Key Laboratory of Digital Quality Evaluation of Chinese Materia Medical of State Administration of TCM, China; Engineering & Technology Research Center for Chinese Materia Medical Quality of Guangdong Province, Guangdong Pharmaceutical University, Guangzhou, China.
  • 2 State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China.
  • 3 School of Chinese Medicine, Southern Medical University, Guangzhou, China.
  • 4 College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
PMID: 31928368 DOI: 10.1080/14786419.2020.1712382
Abstract

One new flavanonol 4 H-​1-​benzopyran-​4-​one,2-​(4-​hydroxyphenyl)​-​3,​7-​dihydroxy-​5-​methoxy-​8-​[5-​methyl-​2-​(1-​methylethenyl)​-​4-​hexenyl]​(21), and twenty-six known compounds 1-20, 22-27 were isolated from the dried root of Sophora flavescens (S. flavescens) in this chemical study. Their structures were elucidated according to the spectroscopic and spectrometric methods. All the isolated compounds were evaluated for their cytotoxicity against lung Cancer A549 cells and colon Cancer HCT116 cells. Among them, compound 21 showed relatively predominant cell proliferation inhibition effect on the two tumor cell lines. Moreover, it induced cells Apoptosis as evidenced by the Annexin V/PI double staining assay as well as the increased cleaved-PARP expression. The aforementioned data indicated that the Flavonoids of S. flavescens have potential anti-cancer effect.

Keywords

Sophora flavescens; apoptosis; cancer; cytotoxicity; flavonoids.

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