2. Academic Validation
  3. Orthoscuticellines A-E, β-Carboline Alkaloids from the Bryozoan Orthoscuticella ventricosa Collected in Australia

Orthoscuticellines A-E, β-Carboline Alkaloids from the Bryozoan Orthoscuticella ventricosa Collected in Australia

  • J Nat Prod. 2020 Feb 28;83(2):422-428. doi: 10.1021/acs.jnatprod.9b00933.
Guy Kleks 1 2,  Sandra Duffy 3,  Leonardo Lucantoni 3,  Vicky M Avery 3,  Anthony R Carroll 1 2
Affiliations

Affiliations

  • 1 Environmental Futures Research Institute , Griffith University , Gold Coast , QLD 4222 , Australia.
  • 2 Griffith Institute for Drug Discovery , Griffith University , Brisbane , QLD 4111 , Australia.
  • 3 Discovery Biology, Griffith Institute for Drug Discovery , Griffith University , Brisbane , QLD 4111 , Australia.
PMID: 31961680 DOI: 10.1021/acs.jnatprod.9b00933
Abstract

Antiplasmodial high-throughput screening of extracts derived from marine invertebrates collected from northern NSW, Australia, resulted in the methanol extract of the bryozoan Orthoscuticella ventricosa being identified as inhibitory toward the 3D7 strain of Plasmodium falciparum. Purification of this extract resulted in two new bis-β-carbolines that possess a cyclobutane moiety, orthoscuticellines A and B (1 and 2), three new β-carboline Alkaloids, orthoscuticellines C-E (3-5), and six known compounds, 1-ethyl-4-methylsulfone-β-carboline (6), 1-ethyl-β-carboline (7), 1-acetyl-β-carboline (8) 1-(1'-hydroxyethyl)-β-carboline (9), 1-methoxycarbonyl-β-carboline (10), and 1-vinyl-β-carboline (11). The structures of all compounds were determined from analysis of MS and 1D and 2D NMR data. The compounds showed modest antiplasmodial activity against P. falciparum in the range of 12-21 μM.

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