2. Academic Validation
  3. Early recruited neutrophils promote asthmatic inflammation exacerbation by release of neutrophil elastase

Early recruited neutrophils promote asthmatic inflammation exacerbation by release of neutrophil elastase

  • Cell Immunol. 2020 Jun;352:104101. doi: 10.1016/j.cellimm.2020.104101.
Qingyu Weng 1,  Chen Zhu 1,  Kua Zheng 1,  Yinfang Wu 1,  Lingling Dong 1,  Yanping Wu 1,  Miao Li 1,  Jiaxin Shen 1,  Songmin Ying 1,  Huahao Shen 2,  Zhihua Chen 3,  Wen Li 4
Affiliations

Affiliations

  • 1 Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China.
  • 2 Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China. Electronic address: huahaoshen@zju.edu.cn.
  • 3 Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China. Electronic address: zhihuachen@zju.edu.cn.
  • 4 Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China. Electronic address: liwen@zju.edu.cn.
PMID: 32278493 DOI: 10.1016/j.cellimm.2020.104101
Abstract

Neutrophils can regulate adaptive immune responses and contribute to chronic inflammation including asthma. However, the roles and mechanisms of neutrophils in initiating eosinophilic airway inflammation remain incompletely understood. Neutrophil Elastase (NE) is a component of azurophilic granules and a serine protease with potent functions during inflammation. Here, we showed that neutrophils were early recruited at the onset of asthmatic inflammation by related chemokines. Furthermore, neutrophils could capture allergens and release NE to promote neutrophil aggregation at first. Then they prompt eosinophil infiltration and amplify type 2 immune responses in later phases. Also, this process can be rescued by administration of the NE inhibitor (GW311616). Our data collectively indicate that neutrophils could contribute to asthmatic inflammation by releasing NE.

Keywords

Asthma; Elastase; Inflammation; Neutrophil.

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