2. Academic Validation
  3. Bioactive Compounds from the Aerial Parts of Evolvulus linarioides

Bioactive Compounds from the Aerial Parts of Evolvulus linarioides

  • J Nat Prod. 2020 May 22;83(5):1515-1523. doi: 10.1021/acs.jnatprod.9b01189.
Laiane C O Pereira 1,  Lucas S Abreu 1,  Joanda P R E Silva 1,  Francisca S V L Machado 1,  Cinthia S Queiroga 1,  Renan F do Espı Rito-Santo 2,  Diego F de Agnelo-Silva 3,  Cristiane F Villarreal 3,  Maria de F Agra 1,  Marcus T Scotti 1,  Vicente C de O Costa 1,  Josean F Tavares 1,  Marcelo S da Silva 1
Affiliations

Affiliations

  • 1 Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraı́ba, João Pessoa, Brazil.
  • 2 Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Brazil.
  • 3 School of Pharmacy, Federal University of Bahia, Salvador, Brazil.
PMID: 32364737 DOI: 10.1021/acs.jnatprod.9b01189
Abstract

Three new caryophyllane-type sesquiterpenoids, linariophyllenes A-C (1-3), two new hamamelitol derivatives, linaritols A (4) and B (5), two new chromones, linariosides A (6) and B (7), and three known chromones, cnidimol C (8), monnieriside A (9), and undulatoside A (10), were identified from the aerial parts of Evolvulus linarioides. The structures of these compounds were elucidated by NMR, MS, and IR data. The absolute configurations of compounds 1-5 and 7 were established via electronic circular dichroism data. The anti-inflammatory potential of compounds 1-5 and 7-10 was evaluated by determining their ability to inhibit the production of nitric oxide (NO) and proinflammatory cytokine IL-1β by stimulated J774 macrophages. Compounds tested at noncytotoxic concentrations inhibited NO production by macrophages, exhibiting IC50 values between 17.8 and 66.2 μM, and inhibited IL-1β production by stimulated macrophages by 72.7-96.2%.

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