2. Academic Validation
  3. Hederacoside-C protects against AGEs-induced ECM degradation in mice chondrocytes

Hederacoside-C protects against AGEs-induced ECM degradation in mice chondrocytes

  • Int Immunopharmacol. 2020 Jul:84:106579. doi: 10.1016/j.intimp.2020.106579.
Hai-Chao Xu 1,  Bin Wu 2,  Yi-Ming Ma 1,  Hao Xu 1,  Zhong-Hai Shen 2,  Sheng Chen 1
Affiliations

Affiliations

  • 1 Department of Orthopaedics, Shaoxing Second Hospital, Shaoxing, China.
  • 2 Department of Orthopaedics, The Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, China.
PMID: 32413742 DOI: 10.1016/j.intimp.2020.106579
Abstract

Hederacoside-C (HDC), a natural compound extracted from the leaves of Hedera helix with inflammation modulatory properties in variety of disorders. In this study, we investigated the latent mechanism of HDC in alleviating of the progress of OA in vitro experiment. The results showed that HDC pretreatment suppressed the advanced glycation end-products (AGEs) induced over-regulation of ROS level and inflammatory factors. Moreover, HDC also downregulate the degradation of ECM induced by AGEs. Mechanistically, the HDC suppressed NF-κB signaling pathway in chondrocyte. To sum up, this study indicated HDC possessed a new potential therapeutic option in osteoarthritis.

Keywords

AGEs; Chondrocytes; Hederacoside-C.

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