2. Academic Validation
  3. SFPH proteins as therapeutic targets for a myriad of diseases

SFPH proteins as therapeutic targets for a myriad of diseases

  • Bioorg Med Chem Lett. 2020 Nov 15;30(22):127600. doi: 10.1016/j.bmcl.2020.127600.
Dong Wang 1,  Redouane Tabti 2,  Sabria Elderwish 2,  Amel Djehal 3,  Nora Chouha 4,  Franck Pinot 5,  Peng Yu 1,  Canan G Nebigil 2,  Laurent Désaubry 6
Affiliations

Affiliations

  • 1 Sino-French Joint Lab of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology, Tianjin University of Science and Technology, Tianjin, China.
  • 2 INSERM-University of Strasbourg, Regenerative Nanomedicine Laboratory (UMR1260), Faculty of Medicine, FMTS, Strasbourg, France.
  • 3 Superior National School Biotechnology Taoufik Khaznadar, Constantine, Algeria.
  • 4 University of Batna 2, Faculty of Biology, Batna, Algeria.
  • 5 University of Strasbourg, CNRS, IBMP UPR 2357, Strasbourg, France.
  • 6 Sino-French Joint Lab of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology, Tianjin University of Science and Technology, Tianjin, China; INSERM-University of Strasbourg, Regenerative Nanomedicine Laboratory (UMR1260), Faculty of Medicine, FMTS, Strasbourg, France. Electronic address: desaubry@unistra.fr.
PMID: 33035678 DOI: 10.1016/j.bmcl.2020.127600
Abstract

The stomatin/prohibitin/flotillin/HflK/HflC (SPFH) domain is present in an evolutionarily conserved family of proteins that regulate a myriad of signaling pathways in archaea, bacteria and eukaryotes. The most studied SPFH proteins, prohibitins, have already been targeted by different families of small molecules to induce Anticancer, cardioprotective, anti-inflammatory, Antiviral, and antiosteoporotic activities. Ligands of Other SPFH proteins have also been identified and shown to act as anesthetics, anti-allodynia, Anticancer, and anti-inflammatory agents. These findings indicate that modulators of human or Bacterial SPFH proteins can be developed to treat a wide variety of human disorders.

Keywords

Allodynia; Anesthesia; Cancer; Drug discovery; Infectious diseases; Lipid rafts; Scaffold proteins.

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