1. Academic Validation
  2. Antiplasmodial Alkaloids from the Australian Bryozoan Amathia lamourouxi

Antiplasmodial Alkaloids from the Australian Bryozoan Amathia lamourouxi

  • J Nat Prod. 2020 Nov 25;83(11):3435-3444. doi: 10.1021/acs.jnatprod.0c00929.
Guy Kleks 1 2 Darren C Holland 1 2 Emily K Kennedy 2 3 Vicky M Avery 2 3 Anthony R Carroll 1 2
Affiliations

Affiliations

  • 1 Environmental Futures Research Institute, Griffith University, Gold Coast, QLD 4222, Australia.
  • 2 Griffith Institute for Drug Discovery, Griffith University, Brisbane, QLD 4111, Australia.
  • 3 Discovery Biology, Griffith University, Brisbane, QLD 4111, Australia.
Abstract

An extract from the bryozoan Amathia lamourouxi with antiplasmodial activity was identified through high-throughput screening of an Australian marine invertebrate extract library against Plasmodium falciparum. Chemical investigation of A. lamourouxi resulted in the isolation of six new brominated Alkaloids, convolutamines K and L (1 and 2), volutamides F-H (3-5), and 2,5-dibromo-1-methyl-1H-indole-3-carbaldehyde (6). Three of the compounds (2-4) displayed moderate to potent antiplasmodial activity against both the chloroquine-sensitive (3D7) and chloroquine-resistant (Dd2) Parasite strains of Plasmodium falciparum with an IC50 range of 0.57-1.7 μM and a high selectivity index against a human cell line (HEK293).

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