2. Academic Validation
  3. A review: Biologically active 3,4-heterocycle-fused coumarins

A review: Biologically active 3,4-heterocycle-fused coumarins

  • Eur J Med Chem. 2021 Feb 15:212:113034. doi: 10.1016/j.ejmech.2020.113034.
Fatemeh Salehian 1,  Hamid Nadri 2,  Leili Jalili-Baleh 1,  Leila Youseftabar-Miri 3,  Syed Nasir Abbas Bukhari 4,  Alireza Foroumadi 5,  Tuba Tüylü Küçükkilinç 6,  Mohammad Sharifzadeh 7,  Mehdi Khoobi 8
Affiliations

Affiliations

  • 1 Pharmaceutical Sciences Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, 1417614411, Iran.
  • 2 Faculty of Pharmacy, and Pharmaceutical Sciences Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
  • 3 Department of Organic Chemistry, Faculty of Pharmaceutical Chemistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
  • 4 Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Aljouf, Sakaka, 2014, Saudi Arabia.
  • 5 Pharmaceutical Sciences Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, 1417614411, Iran; Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
  • 6 Hacettepe University, Faculty of Pharmacy, Department of Biochemistry, Ankara, Turkey.
  • 7 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Toxicology and Poisoning Research Centre, Tehran University of Medical Sciences, Tehran, Iran.
  • 8 Pharmaceutical Sciences Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, 1417614411, Iran; Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: m-khoobi@tums.ac.ir.
PMID: 33276991 DOI: 10.1016/j.ejmech.2020.113034
Abstract

The combination of heterocycles offers a new opportunity to create novel multicyclic compounds having improved biological activity. Coumarins are ubiquitous natural heterocycle widely adopted in the design of various biologically active compounds. Fusing different heterocycles with coumarin ring is one of the interesting approaches to generating novel hybrid molecules having highlighted biological activities. In the efforts to develop heterocyclic-fused Coumarins, a wide range of 3,4-heterocycle-fused Coumarins have been introduced bearing outstanding biological activity. The effect of heterocycles annulation at 3,4-positions of coumarin ring on the biological activity of the target structures were discussed. This review focuses on the important progress of 3,4-heterocycle-fused Coumarins providing better insight for medicinal chemists on the design and preparation of biologically active heterocycle-fused Coumarins with a significant therapeutic effect in the future.

Keywords

Antibacterial; Anticholinesterase; Antioxidant; Antipsychotic; Antiviral; Coumarin.

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