2. Academic Validation
  3. Cytotoxic and Anti-Inflammatory Sesquiterpenes from the Whole Plants of Centipeda minima

Cytotoxic and Anti-Inflammatory Sesquiterpenes from the Whole Plants of Centipeda minima

  • J Nat Prod. 2021 Feb 26;84(2):247-258. doi: 10.1021/acs.jnatprod.0c00884.
Peng-Hui Xue 1,  Nan Zhang 1,  Da Liu 2,  Qing-Ran Zhang 3,  Jing-Shi Duan 2,  Ya-Qin Yu 1,  Jin-Yan Li 1,  Shi-Jie Cao 1,  Feng Zhao 3,  Ning Kang 2,  Feng Qiu 1
Affiliations

Affiliations

  • 1 School of Chinese Materia Medica and State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, People's Republic of China.
  • 2 School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, People's Republic of China.
  • 3 School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai 264005, People's Republic of China.
PMID: 33533247 DOI: 10.1021/acs.jnatprod.0c00884
Abstract

Sixteen new sesquiterpene lactones (1-16) along with 13 known analogues (17-29) were isolated from the whole Plants of Centipeda minima. The structures of 1-16 were delineated by the combination of NMR spectroscopic experiments, HRESIMS, single-crystal X-ray diffraction analyses, and ECD spectra. Compounds 23-26 showed potent cytotoxicity against Hela, HCT-116, and HepG2 cells with IC50 values of 0.8-2.6, 0.4-3.3, and 1.1-2.6 μM, respectively. Compounds 8, 15, and 24 exhibited significant inhibitory activity on the production of nitric oxide in the lipopolysaccharide-activated RAW 264.7 mouse macrophage cell line, with IC50 values ranging from 0.1 to 0.2 μM.

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