2. Academic Validation
  3. Magnesium supplementation enhances mTOR signalling to facilitate myogenic differentiation and improve aged muscle performance

Magnesium supplementation enhances mTOR signalling to facilitate myogenic differentiation and improve aged muscle performance

  • Bone. 2021 May;146:115886. doi: 10.1016/j.bone.2021.115886.
Yuantong Liu 1,  Qinghe Wang 2,  Zengfu Zhang 3,  Runhan Fu 3,  Tianjian Zhou 4,  Canling Long 2,  Tongzhong He 2,  Dazhi Yang 5,  Zhizhong Li 6,  Songlin Peng 7
Affiliations

Affiliations

  • 1 Department of Spine Surgery, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, Shenzhen 518020, China; The First Affiliated Hospital, Jinan University, Guangzhou 510630, China.
  • 2 Department of Spine Surgery, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, Shenzhen 518020, China.
  • 3 School of Medicine, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
  • 4 Shenzhen Key Laboratory of Tissue and Functional Reconstruction of Sports System, The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518020, China.
  • 5 Department of Spine Surgery, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, Shenzhen 518020, China. Electronic address: yangdazhi1111@163.com.
  • 6 The First Affiliated Hospital, Jinan University, Guangzhou 510630, China. Electronic address: lizhizhongjd@163.com.
  • 7 Department of Spine Surgery, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, Shenzhen 518020, China; Shenzhen Key Laboratory of Tissue and Functional Reconstruction of Sports System, The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518020, China. Electronic address: songlin824@gmail.com.
PMID: 33592327 DOI: 10.1016/j.bone.2021.115886
Abstract

Magnesium (Mg2+), as an essential mineral, supports and sustains the health and activity of the organs of the human body. Despite some clinical evidence on the association of Mg2+ deficiency with muscle regeneration dysfunction and sarcopenia in older-aged individuals, there is no consensus on the action mode and molecular mechanism by which Mg2+ influences aged muscle size and function. Here, we identified the appropriate Mg2+ environment that promotes the myogenic differentiation and myotube hypertrophy in both C2C12 myoblast and primary aged muscle stem cell (MuSC). Through animal experiments, we demonstrated that Mg2+ supplementation in aged mice significantly promotes muscle regeneration and conserves muscle mass and strength. Mechanistically, Mg2+ stimulation activated the mammalian target of rapamycin (mTOR) signalling, inducing the myogenic differentiation and protein synthesis, which consequently offers protections against the age-related decline in muscle regenerative potential and muscle mass. These findings collectively provide a promising therapeutic strategy for MuSC dysfunction and sarcopenia through Mg2+ supplementation in the elderly.

Keywords

Aging; Magnesium; Muscle regeneration; Muscle stem cell; Myogenic differentiation; Sarcopenia.

Figures
Products