2. Academic Validation
  3. Antibacterial and Antifungal Polyketides from the Fungus Aspergillus unguis PSU-MF16

Antibacterial and Antifungal Polyketides from the Fungus Aspergillus unguis PSU-MF16

  • J Nat Prod. 2021 May 28;84(5):1498-1506. doi: 10.1021/acs.jnatprod.0c01308.
Praphatsorn Saetang 1,  Vatcharin Rukachaisirikul 1,  Souwalak Phongpaichit 2,  Sita Preedanon 3,  Jariya Sakayaroj 4,  Sarinya Hadsadee 5,  Siriporn Jungsuttiwong 5
Affiliations

Affiliations

  • 1 Division of Physical Science and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand.
  • 2 Division of Biological Science, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand.
  • 3 National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Park, Klong Luang, Pathumthani 12120, Thailand.
  • 4 School of Science, Walailak University, Thasala, Nakhonsithammarat 80161, Thailand.
  • 5 Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ubon Ratchathani University, Ubon Ratchathani 34190, Thailand.
PMID: 33861594 DOI: 10.1021/acs.jnatprod.0c01308
Abstract

Seven new polyketides including a phenol (1), two diphenyl ethers (2 and 3), two depsidones (4 and 5), and two phthalides (6 and 7) were isolated from the fungus Aspergillus unguis PSU-MF16 along with 27 known compounds. Their structures were determined by extensive spectroscopic analysis. The absolute configurations of 1 and 4-7 were established using comparative analyses of calculated and experimental ECD spectra. Among the new metabolites, 2 exhibited the best antimicrobial activity against Staphylococcus aureus, methicillin-resistant S. aureus, and Microsporum gypseum with equal MIC values of 16 μg/mL. In addition, known emeguisin A displayed potent antimicrobial activity against S. aureus, methicillin-resistant S. aureus, and Cryptococcus neoformans with equal MIC values of 0.5 μg/mL, compared with the standard drugs, vancomycin and amphotericin B. The structure-activity relationship study of the isolated compounds for antimicrobial activity is discussed.

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