2. Academic Validation
  3. Anticancer activities of dietary benzyl isothiocyanate: A comprehensive review

Anticancer activities of dietary benzyl isothiocyanate: A comprehensive review

  • Pharmacol Res. 2021 Jul:169:105666. doi: 10.1016/j.phrs.2021.105666.
Thao Nhu Dinh 1,  Marie-Odile Parat 2,  Yong Sze Ong 3,  Kooi Yeong Khaw 4
Affiliations

Affiliations

  • 1 School of Pharmacy, Monash University Malaysia, Bandar Sunway, Selangor Darul Ehsan, Malaysia.
  • 2 School of Pharmacy, University of Queensland, 20 Cornwall Street, Woolloongabba, QLD 4102, Australia.
  • 3 School of Pharmacy, Monash University Malaysia, Bandar Sunway, Selangor Darul Ehsan, Malaysia. Electronic address: Ong.YongSze@monash.edu.
  • 4 School of Pharmacy, Monash University Malaysia, Bandar Sunway, Selangor Darul Ehsan, Malaysia. Electronic address: khaw.kooiyeong@monash.edu.
PMID: 33989764 DOI: 10.1016/j.phrs.2021.105666
Abstract

Benzyl isothiocyanate (BITC) is one of the common isothiocyanates found in Cruciferous vegetables such as broccoli, cabbage or watercress. Preclinical studies report of its effectiveness in the prevention and treatment against several cancers. This review aims to report and discuss findings on Anticancer activities of BITC and its modes of action against 14 types of Cancer. A literature search was conducted using the keywords "BITC" and "anticancer" from PubMed, Google Scholar and CINAHL Plus to obtain relevant research articles. This review highlights the Anticancer efficacy of BITC through modulation of various signaling pathways involved in Apoptosis, cell proliferation, cell cycle arrest, metastasis, angiogenesis, Autophagy and the effects of BITC in combination with other drugs. With the available pharmacology evidence, we conclude that further studies are needed to validate its effectiveness in humans for further development and translation into prophylaxis or therapy by promoting optimal therapeutic effects and minimizing toxicity in Cancer treatment.

Keywords

Anticancer; Benzyl isothiocyanate; Chemopreventive; Chemotherapeutic; Natural compound.

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