2. Academic Validation
  3. [11]-Chaetoglobosins from Pseudeurotium bakeri Induce G2/M Cell Cycle Arrest and Apoptosis in Human Cancer Cells

[11]-Chaetoglobosins from Pseudeurotium bakeri Induce G2/M Cell Cycle Arrest and Apoptosis in Human Cancer Cells

  • J Nat Prod. 2021 Jul 23;84(7):1904-1914. doi: 10.1021/acs.jnatprod.0c01335.
Fang-Fang Duan 1,  Lin Liu 1,  Ying Gao 1,  Xiao-Gang Peng 1,  Xiang-Gao Meng 2,  Han-Li Ruan 1
Affiliations

Affiliations

  • 1 Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
  • 2 College of Chemistry, Central China Normal University, Wuhan 430079, People's Republic of China.
PMID: 34176266 DOI: 10.1021/acs.jnatprod.0c01335
Abstract

Twelve new [11]-chaetoglobosins, chaetopseudeurins A-L (1-12), were identified from the fermentation of the endophytic fungus Pseudeurotium bakeri P1-1-1. Their structures with absolute configurations were elucidated by detailed interpretation of NMR spectroscopy, mass spectrometry, and single-crystal X-ray diffraction. Compounds 2 and 5-7 exhibited significant cytotoxicities against seven human Cancer cell lines, with IC50 values ranging from 4.7 ± 1.0 to 12.2 ± 0.7 μM, and induced G2/M cell cycle arrest and Apoptosis in MCF-7 and A427 cells dose dependently. Western blot analysis showed that compound 2 induced Apoptosis of MCF-7 cells via the Bcl-2/Caspase-3/PARP pathway.

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