1. Academic Validation
  2. Ivermectin: A Promising Therapeutic for Fighting Malaria. Current Status and Perspective

Ivermectin: A Promising Therapeutic for Fighting Malaria. Current Status and Perspective

  • J Med Chem. 2021 Jul 22;64(14):9711-9731. doi: 10.1021/acs.jmedchem.1c00498.
Lovepreet Singh 1 Kamaljit Singh 1
Affiliations

Affiliation

  • 1 Department of Chemistry, UGC Centre for Advanced Studies-II, Guru Nanak Dev University, Amritsar-143 005, India.
Abstract

Finding new chemotherapeutic interventions to treat malaria through repurposing of time-tested drugs and rigorous design of new drugs using tools of rational drug design remains one of the most sought strategies at the disposal of medicinal chemists. Ivermectin, a semisynthetic derivative of avermectin B1, is among the efficacious drugs used in mass drug administration drives employed against onchocerciasis, lymphatic filariasis, and several Other parasitic diseases in humans. In this review, we present the prowess of ivermectin, a potent endectocide, in the control of malaria through vector control to reduce Parasite transmission combined with efficacious chemoprevention to reduce malaria-related fatalities.

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