2. Academic Validation
  3. Cryptoyunnanones A-H, Complex Flavanones from Cryptocarya yunnanensis

Cryptoyunnanones A-H, Complex Flavanones from Cryptocarya yunnanensis

  • J Nat Prod. 2021 Aug 27;84(8):2209-2216. doi: 10.1021/acs.jnatprod.1c00287.
Qian He 1,  Yue Fan 1,  Yu Liu 1,  Li Rao 1,  Yun-Xia You 1,  Yu Su 1,  Zhen Zhou 1,  You-Kai Xu 2,  Chuan-Rui Zhang 1 3
Affiliations

Affiliations

  • 1 Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, People's Republic of China.
  • 2 Key Laboratory of Tropical Plant Resource and Sustainable Use, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Menglun, Yunnan 666303, People's Republic of China.
  • 3 State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
PMID: 34282909 DOI: 10.1021/acs.jnatprod.1c00287
Abstract

Eight new complex flavanones with a novel linkage, cryptoyunnanones A-H (1-8), together with four known α-pyrones, were isolated from the leaves and twigs of Cryptocarya yunnanensis. The structures of 1-8 including their absolute configurations were characterized by spectroscopic data analysis and single-crystal X-ray crystallography. Plausible biosynthetic pathways for the formation of compounds 1-8 were proposed. Compounds 1-4 exhibited cytotoxicity against HCT-116, MDA-MB-231, and PC-3 Cancer cells with IC50 values from 6.4 to 9.1 μM.

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