2. Academic Validation
  3. Comutagenic effect of norharman and harman with 2-acetylaminofluorene derivatives

Comutagenic effect of norharman and harman with 2-acetylaminofluorene derivatives

  • Proc Natl Acad Sci U S A. 1978 Feb;75(2):928-30. doi: 10.1073/pnas.75.2.928.
K Umezawa,  A Shirai,  T Matsushima,  T Sugimura
PMID: 345280 DOI: 10.1073/pnas.75.2.928
Abstract

Norharman enhanced the known mutagenicity of 2-acetylaminofluorene derivatives in the Salmonella test system. The mutagenicities of 2-acetylaminofluorene, 2-aminofluorene, and N-hydroxy-2-acetylaminofluorene were enhanced by norharman only when rat liver microsomal Enzymes were added, whereas the mutagenicity of N-acetoxy-2-acetylaminofluorene was increased in the absence of microsomal Enzymes. Harman also increased mutagenesis, althouth less so than norharman.

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