The roles of GTPase-activating proteins in regulated cell death and tumor immunity

J Hematol Oncol. 2021 Oct 18;14(1):171. doi: 10.1186/s13045-021-01184-1.

Hua He ^# ¹ ², Jingjing Huang ^# ¹ ², Sufang Wu ^# ¹ ², Shiyao Jiang ¹ ², Lu Liang ¹ ², Yueying Liu ¹ ², Wenbing Liu ³, Li Xie ³, Yongguang Tao ⁴, Yiqun Jiang ⁵ ⁶, Li Cong ⁷ ⁸

Affiliations

1 The Key Laboratory of Model Animal and Stem Cell Biology in Hunan Province, Hunan Normal University, Changsha, 410013, Hunan, People's Republic of China.
2 School of Medicine, Hunan Normal University, Changsha, 410013, Hunan, People's Republic of China.
3 Department of Head and Neck Surgery, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, Hunan, People's Republic of China.
4 Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Department of Pathology, Xiangya Hospital, School of Basic Medicine, Central South University, Changsha, 410078, Hunan, People's Republic of China.
5 The Key Laboratory of Model Animal and Stem Cell Biology in Hunan Province, Hunan Normal University, Changsha, 410013, Hunan, People's Republic of China. jiangyiqun@hunnu.edu.cn.
6 School of Medicine, Hunan Normal University, Changsha, 410013, Hunan, People's Republic of China. jiangyiqun@hunnu.edu.cn.
7 The Key Laboratory of Model Animal and Stem Cell Biology in Hunan Province, Hunan Normal University, Changsha, 410013, Hunan, People's Republic of China. congli@hunnu.edu.cn.
8 School of Medicine, Hunan Normal University, Changsha, 410013, Hunan, People's Republic of China. congli@hunnu.edu.cn.
# Contributed equally.

PMID: 34663417 DOI: 10.1186/s13045-021-01184-1

Abstract

GTPase-activating protein (GAP) is a negative regulator of GTPase protein that is thought to promote the conversion of the active GTPase-GTP form to the GTPase-GDP form. Based on its ability to regulate GTPase proteins and Other domains, GAPs are directly or indirectly involved in various cell requirement processes. We reviewed the existing evidence of GAPs regulating regulated cell death (RCD), mainly Apoptosis and Autophagy, as well as some novel RCDs, with particular attention to their association in diseases, especially Cancer. We also considered that GAPs could affect tumor immunity and attempted to link GAPs, RCD and tumor immunity. A deeper understanding of the GAPs for regulating these processes could lead to the discovery of new therapeutic targets to avoid pathologic cell loss or to mediate Cancer cell death.

Keywords

GTPase-activating proteins; Regulated cell death; Tumor immunity.

Name
Email *

	Sorry, but the email address you supplied was invalid.