2. Academic Validation
  3. Prevalence and trend of allergen sensitization in patients with a diagnosis of stasis dermatitis referred for patch testing, North American contact dermatitis group data, 2001-2016

Prevalence and trend of allergen sensitization in patients with a diagnosis of stasis dermatitis referred for patch testing, North American contact dermatitis group data, 2001-2016

  • Arch Dermatol Res. 2022 Nov;314(9):857-867. doi: 10.1007/s00403-021-02295-y.
Jonathan I Silverberg # 1,  Alexander Hou # 2,  Erin M Warshaw 3 4 5,  Howard I Maibach 6,  Donald V Belsito 7,  Joel G DeKoven 8,  Kathryn A Zug 9,  James S Taylor 10,  Denis Sasseville 11,  Anthony F Fransway 12,  Vincent A DeLeo 13,  Melanie D Pratt 14,  Margo J Reeder 15,  Amber R Atwater 16,  Joseph F Fowler Jr 17,  Matthew J Zirwas 18,  James G Marks Jr 19
Affiliations

Affiliations

  • 1 Department of Dermatology, School of Medicine, George Washington University, 2150 Pennsylvania Avenue, Suite 2B-425, Washington, DC, 20037, USA. jonathanisilverberg@gmail.com.
  • 2 Department of Dermatology, Feinberg School of Medicine, Northwestern University, Evanston, USA.
  • 3 Department of Dermatology, Park Nicollet Health Services, Minneapolis, MN, USA.
  • 4 Department of Dermatology, University of Minnesota, Minneapolis, MN, USA.
  • 5 Department of Dermatology, Minneapolis Veterans Affairs Medical Center, Minneapolis, USA.
  • 6 Department of Dermatology, University of California San Francisco, San Francisco, USA.
  • 7 Department of Dermatology, Columbia University Irving Medical Center, New York, NY, USA.
  • 8 Division of Dermatology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
  • 9 Department of Dermatology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
  • 10 Department of Dermatology, Cleveland Clinic, Cleveland, OH, USA.
  • 11 Division of Dermatology, Montreal General Hospital, McGill University, Montreal, QC, Canada.
  • 12 Associates in Dermatology, Fort Myers, FL, USA.
  • 13 Department of Dermatology, Keck School of Medicine, Los Angeles, CA, USA.
  • 14 Division of Dermatology, University of Ottawa, Ottawa, ON, Canada.
  • 15 Department of Dermatology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
  • 16 Department of Dermatology, Duke University Medical Center, Durham, NC, USA.
  • 17 Division of Dermatology, University of Louisville, Louisville, KY, USA.
  • 18 Department of Dermatology, Ohio State University, Columbus, USA.
  • 19 Department of Dermatology, Pennsylvania State University, State College, USA.
  • # Contributed equally.
PMID: 34748058 DOI: 10.1007/s00403-021-02295-y
Abstract

Background: Few studies explored the relationship between stasis dermatitis (SD) and allergic contact dermatitis (ACD).

Objective: To examine trends, associations, and clinical relevance of ACD in patients referred for patch testing who had a final SD diagnosis.

Methods: Retrospective analysis from 2001 to 2016 of 38,723 patients from the North American Contact Dermatitis Group.

Results: After patch testing, 303 (0.7%) patients were diagnosed with SD; 46.7% had a concomitant diagnosis of ACD. Patients with vs. without a final SD diagnosis had similar proportions of ≥ 1 positive allergic reaction (59.7% vs. 64.7%; Chi-square, P = 0.0724) but higher odds of allergic reactions to fragrance mix I, bacitracin, quaternium-15, Myroxylon pereirae, benzalkonium chloride, ethyleneurea melamine formaldehyde, diazolidinyl urea, and propylene glycol. The most commonly relevant allergens in patients with final SD diagnosis were fragrance mix I, Myroxylon pereirae, bacitracin, quaternium-15, and formaldehyde. The most common allergen sources were personal care products, topical medications and other health aid products.

Conclusion: Nearly half of patients with a final SD diagnosis were also diagnosed with ACD, supporting the role of patch testing in select SD patients.

Keywords

Allergic contact dermatitis; Dermatitis; Epidemiology; Foot; Generalized; Health; Hypersensitivity; Irritant contact dermatitis; Itch; Leg; Patch test; Pruritus; Rash; Stasis eczema.

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