2. Academic Validation
  3. Asthma reduces glioma formation by T cell decorin-mediated inhibition of microglia

Asthma reduces glioma formation by T cell decorin-mediated inhibition of microglia

  • Nat Commun. 2021 Dec 8;12(1):7122. doi: 10.1038/s41467-021-27455-6.
Jit Chatterjee 1,  Shilpa Sanapala 1,  Olivia Cobb 1,  Alice Bewley 1,  Andrea K Goldstein 1,  Elizabeth Cordell 1,  Xia Ge 2,  Joel R Garbow 2,  Michael J Holtzman 3,  David H Gutmann 4
Affiliations

Affiliations

  • 1 Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
  • 2 Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
  • 3 Department of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO, USA.
  • 4 Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA. gutmannd@wustl.edu.
PMID: 34880260 DOI: 10.1038/s41467-021-27455-6
Abstract

To elucidate the mechanisms underlying the reduced incidence of brain tumors in children with Neurofibromatosis type 1 (NF1) and asthma, we leverage Nf1 optic pathway glioma (Nf1OPG) mice, human and mouse RNAseq data, and two different experimental asthma models. Following ovalbumin or house dust Mite asthma induction at 4-6 weeks of age (WOA), Nf1OPG mouse optic nerve volumes and proliferation are decreased at 12 and 24 WOA, indicating no tumor development. This inhibition is accompanied by reduced expression of the microglia-produced optic glioma mitogen, Ccl5. Human and murine T cell transcriptome analyses reveal that inhibition of microglia Ccl5 production results from increased T cell expression of decorin, which blocks Ccl4-mediated microglia Ccl5 expression through reduced microglia NFκB signaling. Decorin or NFκB inhibitor treatment of Nf1OPG mice at 4-6 WOA inhibits tumor formation at 12 WOA, thus establishing a potential mechanistic etiology for the attenuated glioma incidence observed in children with asthma.

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