2. Academic Validation
  3. Nanoparticle-assembled bioadhesive coacervate coating with prolonged gastrointestinal retention for inflammatory bowel disease therapy

Nanoparticle-assembled bioadhesive coacervate coating with prolonged gastrointestinal retention for inflammatory bowel disease therapy

  • Nat Commun. 2021 Dec 9;12(1):7162. doi: 10.1038/s41467-021-27463-6.
Pengchao Zhao  # 1,  Xianfeng Xia  # 2 3,  Xiayi Xu  # 1,  Kevin Kai Chung Leung 4,  Aliza Rai 4,  Yingrui Deng 1,  Boguang Yang 1,  Huasheng Lai 4,  Xin Peng 1,  Peng Shi 5 6,  Honglu Zhang 5 6,  Philip Wai Yan Chiu 7 8 9,  Liming Bian 10 11
Affiliations

Affiliations

  • 1 Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong, 999077, China.
  • 2 Department of Endoscopy, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, 510000, China.
  • 3 Chow Yuk Ho Technology Centre for Innovative Medicine, The Chinese University of Hong Kong, Hong Kong, 999077, China.
  • 4 Department of Surgery, Institute of Digestive Disease, State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, 999077, China.
  • 5 School of Biomedical Sciences and Engineering, Guangzhou International Campus, South China University of Technology, Guangzhou, 511442, China.
  • 6 National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China.
  • 7 Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong, 999077, China. philipchiu@surgery.cuhk.edu.hk.
  • 8 Chow Yuk Ho Technology Centre for Innovative Medicine, The Chinese University of Hong Kong, Hong Kong, 999077, China. philipchiu@surgery.cuhk.edu.hk.
  • 9 Department of Surgery, Institute of Digestive Disease, State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, 999077, China. philipchiu@surgery.cuhk.edu.hk.
  • 10 School of Biomedical Sciences and Engineering, Guangzhou International Campus, South China University of Technology, Guangzhou, 511442, China. bianlm@scut.edu.cn.
  • 11 National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China. bianlm@scut.edu.cn.
  • # Contributed equally.
PMID: 34887414 DOI: 10.1038/s41467-021-27463-6
Abstract

A key challenge for the effective treatment of gastrointestinal diseases including inflammatory bowel disease is to develop an orally administered drug delivery system capable of prolonged retention in the gastrointestinal tract. Herein we report a bioadhesive liquid coacervate based on hydrogen bonding-driven nanoparticle assembly. Free from electrostatic interactions, our fluid nanoparticle-assembled coacervate demonstrates significant pH- and salt-independent structural stability and forms a physically adhesive coating on a large surface area of intestinal tract with an extended residence time of more than 2 days to mediate the sustained release of preloaded water-soluble small molecule drugs in vivo. The orally administered drug-laden nanoparticle-assembled coacervate significantly mitigates the symptoms of inflammatory bowel disease, restores the diversity of gut microbiota, reduces systemic drug exposure, and improves the therapeutic efficacy in a rat acute colitis model compared with the oral administration of the same amount of drug in solution form. We suggest that the nanoparticle-assembled coacervate provides a promising drug delivery platform for management and treatment of numerous gastrointestinal diseases where controlled drug release with extended residence time is desired.

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