2. Academic Validation
  3. Intestinal Alkaline Phosphatase: A Review of This Enzyme Role in the Intestinal Barrier Function

Intestinal Alkaline Phosphatase: A Review of This Enzyme Role in the Intestinal Barrier Function

  • Microorganisms. 2022 Mar 30;10(4):746. doi: 10.3390/microorganisms10040746.
Gilberto Maia Santos 1,  Shámila Ismael 1 2 3,  Juliana Morais 1 2 3,  João R Araújo 1 2,  Ana Faria 1 2 3,  Conceição Calhau 1 2 4,  Cláudia Marques 1 2
Affiliations

Affiliations

  • 1 Nutrition and Metabolism, NOVA Medical School, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, 1169-056 Lisboa, Portugal.
  • 2 CINTESIS-Center for Health Technology Services Research, NOVA Medical School, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, 1169-056 Lisboa, Portugal.
  • 3 CHRC-Comprehensive Health Research Centre, CEDOC-Chronic Diseases Research Center, NOVA Medical School, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, 1169-056 Lisboa, Portugal.
  • 4 Unidade Universitária Lifestyle Medicine José de Mello Saúde by NOVA Medical School, 1169-056 Lisboa, Portugal.
PMID: 35456797 DOI: 10.3390/microorganisms10040746
Abstract

Intestinal Alkaline Phosphatase (IALP) has recently assumed a special relevance, being the subject of study in the prevention and treatment of certain diseases related to leaky gut. This brush border Enzyme (ecto-enzyme) plays an important role in the maintenance of intestinal microbial homeostasis and intestinal barrier function through its ability to dephosphorylate lipopolysaccharide (LPS). This review addresses how IALP and intestinal barrier dysfunction may be implicated in the pathophysiology of specific diseases such as inflammatory bowel disease, necrotizing enterocolitis, and metabolic syndrome. The use of IALP as a possible biomarker to assess intestinal barrier function and strategies to modulate IALP activity are also discussed.

Keywords

inflammatory bowel disease; intestinal alkaline phosphatase; intestinal barrier function; low-grade chronic inflammation; metabolic dysfunction; necrotizing enterocolitis; obesity.

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