2. Academic Validation
  3. Luteolin attenuated cisplatin-induced cardiac dysfunction and oxidative stress via modulation of Keap1/Nrf2 signaling pathway

Luteolin attenuated cisplatin-induced cardiac dysfunction and oxidative stress via modulation of Keap1/Nrf2 signaling pathway

  • Free Radic Res. 2022 Feb;56(2):209-221. doi: 10.1080/10715762.2022.2067042.
Yajun Qi 1 2,  Shuang Fu 3 4,  Donggen Pei 5,  Qilu Fang 1 2,  Wenxiu Xin 1 2,  Xiaohong Yuan 3 4,  Yingying Cao 1 2,  Qi Shu 1 2,  Xiufang Mi 1 2,  Fang Luo 1 2
Affiliations

Affiliations

  • 1 Department of Pharmacy, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, Zhejiang, China.
  • 2 Department of Pharmacy, Institute of Cancer and Basic Medicine (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang, China.
  • 3 Department of Anesthesiology, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, Zhejiang, China.
  • 4 Department of Anesthesiology, Institute of Cancer and Basic Medicine (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang, China.
  • 5 Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing, China.
PMID: 35468014 DOI: 10.1080/10715762.2022.2067042
Abstract

Cardiovascular complications are a well-documented limitation of Cancer chemotherapy. Cisplatin-induced cardiotoxicity threatens the health and life of patients, and limits the application of cisplatin. Oxidative stress is the main mechanism underlying cisplatin-induced cardiac toxicity. Luteolin (Lut) has been reported to possess cardioprotective properties by activating nuclear factor-E2-related factor 2 (Nrf2) -mediated antioxidant response. However, the effect of Lut on cisplatin-induced cardiac damage remains unclear. In this study, we revealed that Lut exerted a protective effect against cisplatin-induced cardiac dysfunction and injury in vivo. In HL-1 cells, Lut was observed to dramatically reduce cisplatin-induced Apoptosis and oxidative stress by modulating the Kelch-like epichlorohydrin-associated protein 1 (Keap1)/Nrf2 pathway. Altogether, these findings suggested that Lut showed promise in attenuating cisplatin-induced cardiac injury and might be considered a protective drug candidate for chemotherapy-associated cardiovascular complications.

Keywords

Keap1; Luteolin; Nrf2; cisplatin; oxidative stress.

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