2. Academic Validation
  3. Platelet changes after a saturated fat meal and their prevention by Dazmegrel, a thromboxane synthetase inhibitor

Platelet changes after a saturated fat meal and their prevention by Dazmegrel, a thromboxane synthetase inhibitor

  • Lipids. 1987 Mar;22(3):159-62. doi: 10.1007/BF02537296.
J J Belch,  A R Saniabadi,  K McLaughlin,  C D Forbes
PMID: 3573995 DOI: 10.1007/BF02537296
Abstract

A saturated fat meal was given to 10 normal males both before and after pretreatment with UK38,485, a thromboxane synthetase inhibitor (Dazmegrel, Pfizer Central Research, Sandwich, Kent, United Kingdom). Following the fat meal at 2 and 4 hr there was laboratory evidence of platelet activation. Dazmegrel lowered baseline platelet activity and lessened platelet activation following the fat meal. This drug should be investigated further as a potential antithrombotic agent.

Figures
Products