1. Academic Validation
  2. Suncheonosides E-M and Benzothioate Derivatives from the Marine-Derived Streptomyces sp. ZSN77

Suncheonosides E-M and Benzothioate Derivatives from the Marine-Derived Streptomyces sp. ZSN77

  • J Nat Prod. 2022 Jul 22;85(7):1771-1778. doi: 10.1021/acs.jnatprod.2c00320.
Miao Jiang 1 Ying Zhang 1 Yuxiao Zhang 1 Zhongjun Ma 1 Jinhui Wang 1
Affiliations

Affiliation

  • 1 Institute of Marine Biology and Pharmacology, Ocean College, Zhejiang University, Zhoushan 316021, People's Republic of China.
Abstract

Thirteen new compounds, including suncheonosides E-M (1-9), four benzothioate derivatives (10-13), and one known compound (14), were identified from the marine-derived Streptomyces sp. ZSN77. Suncheonosides E-M incorporate β-d-glucose, while the reported suncheonosides (A-D) incorporate only l-rhamnose. All of the structures were determined by extensive analysis of NMR spectroscopic and HRESIMS data. Bioactivity evaluation of these compounds showed that 6 had significant activity against PC3 cells with an IC50 value of 4.1 ± 0.1 μM, while compounds 12 and 14 exhibited cytotoxicity against HCT116 cells with IC50 values of 7.3 ± 0.4 and 3.9 ± 0.3 μM, respectively. In addition, compounds 1, 2, 6, 10, and 14 displayed potent in vivo anti-inflammatory efficacy with inhibition of NO production in a dose-dependent manner.

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