2. Academic Validation
  3. A Carabrane-Type Sesquiterpenolide Carabrone from Carpesium cernuum Inhibits SW1990 Pancreatic Cancer Cells by Inducing Ferroptosis

A Carabrane-Type Sesquiterpenolide Carabrone from Carpesium cernuum Inhibits SW1990 Pancreatic Cancer Cells by Inducing Ferroptosis

  • Molecules. 2022 Sep 9;27(18):5841. doi: 10.3390/molecules27185841.
Yi-Dan Zheng 1,  Ying Zhang 2 3,  Jun-Yi Ma 1,  Chun-Yan Sang 2,  Jun-Li Yang 2
Affiliations

Affiliations

  • 1 College of Life Science, Northwest Normal University, Lanzhou 730070, China.
  • 2 CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China.
  • 3 University of Chinese Academy of Sciences, Beijing 100049, China.
PMID: 36144577 DOI: 10.3390/molecules27185841
Abstract

Pancreatic Cancer has an extremely poor prognosis, and the clinical drugs for the treatment of pancreatic Cancer are usually multi-drug combinations. Therefore, it is necessary to search for and find specific new bioactive agents against pancreatic Cancer. Carabrone is a carabrane-type sesquiterpenolide extracted from Carpesium cernuum L., and this natural compound has been reported to be a potential anti-tumor agent. However, there are few reports on the function of carabrone related to anti-tumor activity in pancreatic Cancer. Herein, cell experiments indicated that carabrone had anti-proliferation inhibition and anti-migration and anti-invasion activity against SW1990 cells. Furthermore, the tandem mass spectrometry and network pharmacology analysis showed that this activity may be related to the Ferroptosis and Hippo signaling pathway. Taken together, our results demonstrated that carabrone exhibited prominent anti-pancreatic Cancer activity and could be a promising agent against pancreatic Cancer.

Keywords

Carpesium cernuum L.; SW1990 cells; ferroptosis; natural product; proteomics.

Figures
Products