2. Academic Validation
  3. Preclinical activities of Cassia tora Linn against aging-related diseases

Preclinical activities of Cassia tora Linn against aging-related diseases

  • Expert Rev Mol Med. 2022 Oct 25:24:e43. doi: 10.1017/erm.2022.33.
Sun-Young Hwang 1,  Chang-Su Na 1,  Byeong Cheol Moon 2,  Jung-Hyun Shim 3 4 5,  Mee-Hyun Lee 1
Affiliations

Affiliations

  • 1 College of Korean Medicine, Dongshin University, Naju 58245, Republic of Korea.
  • 2 Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, Naju 58245, Republic of Korea.
  • 3 Department of Pharmacy, College of Pharmacy, Mokpo National University, Jeonnam 58554, Republic of Korea.
  • 4 Department of Biomedicine, Health & Life Convergence Sciences, BK21 FOUR, Mokpo National University, Jeonnam 58554, Republic of Korea.
  • 5 The China-US (Henan) Hormel Cancer Institute, Zhengzhou, Henan 450008, P.R. China.
PMID: 36281483 DOI: 10.1017/erm.2022.33
Abstract

Globally, an aging population is increasing, and aging is a natural physiological process and a major risk factor for all age-related diseases. It seriously threatens personal health and imposes a great economic burden. Therefore, there is a growing scientific interest in strategies for well-aging with prevention and treatment of age-related diseases. The seed, root, stem or leaves of Cassia tora Linn. are useful for anti-bacteria, anti-hyperlipidemia and anti-obesity due to its pharmacological activities such as anti-inflammation and anti-oxidant both in vitro and in vivo. Nevertheless, no clinical trials have been attempted so far, therefore here we would like to understand the current preclinical activities for aging-related disease models including cataract, metabolic dysfunction and neurodegeneration, then discuss their preparation for clinical trials and perspectives.

Keywords

Animal model; Cassia tora Linn; antioxidant; disease; preclinical.

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